Pre-organized landscape of T cell surface

T cell activation is initiated by the recognition of specific antigenic peptides and subsequently accomplished complex signaling cascades. These aspects have been extensively studied for decades as pivotal factors in establishment adaptive immunity. However, how receptors or molecules are organized resting state prior to encountering antigens has received less attention. Recent advancements super-resolution microscopy techniques revealed topographically controlled pre-formed organization key involved antigen signal transduction on microvillar projections cells before substantial effort dedicated characterizing topological structure over past decade. This review will summarize our current understanding surface pre-organized T-cell plasma membrane discuss potential role these receptors, which preassembled ligand binding early events cells.